- Commodity name: AutoMCD Pilot
- 产品系列: Nanoparticle Assembly System
For continuous automated preparation of LNP and other nanoparticles.

The Unique AutoMCD Pilot is an automated assembly system for nanoparticles (such as LNP, polymers particles, liposomes, PLGA, etc.) .

The Unique AutoMCD Pilot features a high-precision dual-piston biologically inert pump that ensures stable liquid delivery. It is equipped with user-friendly operating software and various microfluidic chip specifications, effectively controlling particle size to achieve excellent uniformity and encapsulation rates, as well as good inter-batch stability. Additionally, a dilution pump is included for inline dilution.

The Unique AutoMCD series nanoparticle assembly system consists of two high-precision dual-piston infusion pump, inlet valves, , microfluidic chip holder, dilution pump, collection valve, dilution module, etc. The Unique CDSystem workstation software can execute instrument control, method editing, manual control, fraction collection, data acquisition&storage, and user management.

The high-precision dual-piston pump is a parallel dual-piston constant flow pump with two pump heads and four sets of dual-acting one-way valves, with features of high pressure resistance, low pulsation, easy maintenance, stable output flow, high flow accuracy, easy solvent replacement.

The microfluidic chip is designed based on sputtering principles, allowing for the instantaneous mix of two liquid flow under pressure, forming nanoparticles with stable diameters and low PDI.

The Unique CDSystem workstation software, as part of the system, allows for configuration of flow rates, pressure limits, flushing, self-checks and more. It also includes pressure alarm function, enhancing the safety and reliability of the infusion pump and microfluidic chip.

Features

● Superior Metering Liquid Delivery, Patented Technology: Extremely low pulsation ensures uniform particle size.

● Sanitary Design of the Infusion Pump: Utilizes patented technology for cleaning in place (CIP) to prevent cross-contamination.

● Variety of Mixing Chip Specifications:Meets application needs from process development to large-scale production.

● Unique Pressure-Assisted Sputtering Mixing Technology:Ensures particle size uniformity and high encapsulation rates.

● Fluid Pathways Compliant with USP Class VI Standards.

● Software Compliant with FDA 21 CFR Part 11.

Model	Flowrate range	Max productivity
Unique AutoMCD Pilot25	0- 25ml/min	1.5L/h
Unique AutoMCD Pilot100	0- 120ml/min	7.2L/h
Unique AutoMCD Pilot600 GMP	0- 600ml/min	36L/h
Unique AutoMCD Process GMP	0- 1.8L/min	100L/h

Microfluidic chip

Model	Type	Recommended flowrate	Max pressure
Microfluidic chip	ISI-ORI-02	4-12ml/min	1Mpa
Microfluidic chip	MCY-03-G-PEEK	10-40ml/min	1Mpa
Microfluidic chip	MCY-04-G-PEEK	40-80ml/min	1Mpa
Microfluidic chip	MCY-05-G-PEEK	280-360ml/min	1Mpa

Unique AutoMCD Pilot25

Item	Specification
Maximum Pressure Tolerance	0 psi - 1450 psi
Flow Rate Range	0.001 ml/min - 25.000 ml/min
Flow Rate Accuracy	±1% @1-25ml/min
Flow Rate Repeatability	0.5% RSD
Dilution Pump	0.001 ml/min - 100.000 ml/min

Unique AutoMCD Pilot100

Item	Specification
Maximum Pressure Tolerance	0 psi - 1450 psi
Flow Rate Range	0.001 ml/min - 100.000 ml/min（AutoMCD 100）
Flow Rate Accuracy	±1% @1-100ml/min
Flow Rate Repeatability	0.5% RSD
Dilution Pump	0.01-300.00ml/min